The Next America

I have this theory of mine that I am thinking about today.
There are a few problems in North America regarding interstate commerce as well as national influence.
The Quebecians have long had movements to secede from the Canadian Province System.
That said, There is also a movement for a "Cascadia" in the west.  This is theorized to involve the British Columbia State with Vancouver as well as Washington State and portions of Oregon. 
The reason for the Cascadia idea is that there is a growing concern about international commerce between the highly active corridor from Vancouver to Washington and Portland. 
This is in my thoughts never to occur.  The idea was that these states and this province would secede from their unions and form their own nation.  It does make sense in a sense that there would be no tariffs for commerce, but I admit being an American, I see no way that there can be a secession of an American State in this day and age or ever. 
That said, I predict personally that the following will occur:
British Columbia will secede from the Canadian Province System and form a 51st American State.  This in my thoughts would be the state of Cascaic State.  This would ensure that American Laws design all of the commerce and thus the tariff would be eliminated.
The other secesion I predict will happen is that Quebec will ultimately some time secede from Canada.  I do not think that Quebec is stabile enough to be its own Nation, but I predict that it would be the 52nd state of America.  Thus there would be a 52 state Union and I personally do not think this would change the balance of power in any fashion.